P53 Status In Cancer Cell Lines

The tp53 gene network in the post genomic era.

P53 status in cancer cell lines.

A special issue of human mutation has been released. Since then a large number of publications have demonstrated many gofs in numerous cell lines with a variety of p53 mutations summarized in table 1 the gof acquired by mutant p53 is further supported by the finding that patients carrying a tp53 missense mutation leading to expression of a. Strikingly we found discrepancies in the p53 status for 23 88 384 of cell lines for which the p53 status was established independently in two laboratories. When the introduction of mutant p53 into p53 null cells was shown to give rise to a new phenotype.

Using the nci 60 cell line panel as a model widely used in the literature the p53 status could not be ascertained for 13 cell lines due to a lack of homogeneous data in the literature. The p53 mutations in cell lines compendium is a novel and original application that provides an id card for each cell line included in the umd tp53 database. Knowledgebase and statistical tools for the analysis of tp53 gene mutations in human cancers. Several fundamental features of wild type and mutant proteins and their modifications are reviewed as well as animal models and clinical aspects such as recommendations for patient care.

The current version includes 2 000 and 500 cell lines with mutant tp53 and wild type tp53 respectively. The p53 mutations in cell lines compendium.