Nk Cell Therapy Aml

Nk cells as consolidation therapy of acute myeloid leukemia in children adolescents the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. This study investigates an innovative treatment for relapsed or refractory acute myeloid leukemia aml exploiting administration of ex vivo generated allogeneic natural killer nk cells with preceding non myeloablative conditioning chemotherapy with or without subsequent in vivo il 2 cytokine support. It is unknown whether such approaches targeting aml will spare normal hematopoiesis or would need to be used in combination with hematopoietic stem cell transplantation.

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Nk cell therapy aml.

These patients show significant alloreactivity to the aml by donor derived natural killer nk cells making these cells strong candidates for adoptive therapy. Allogeneic hematopoietic stem cell transplantation allo hsct has been recognized as the only curative therapy for patients with acute myeloid leukemia aml. Nk cells expressing a car against myeloid antigens may combine the benefits of targeting aml cells with nk cell mediated killing. Allo hsct s mode of action is primarily attributed to the graft versus leukemia gvl effect mediated by donor t cells and natural killer nk cells.

Nk cells expressing a car against myeloid antigens may combine the benefits of targeting aml cells with nk cell mediated killing. It is unknown whether such approaches targeting aml will spare normal hematopoiesis or would need to be used in combination with hematopoietic stem cell transplantation. This is a prospective phase i iia study. Young acute myeloid leukemia aml patients treated with haploidentical hematopoietic stem cell hsc transplantation demonstrate prolonged survival and diminished rate of relapse.

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