Mini Stem Cell Transplant For Myelofibrosis

Stem cell transplantation.

Mini stem cell transplant for myelofibrosis.

Despite the approval of janus kinase inhibitor treatment in myelofibrosis allogeneic stem cell transplantation remains the only curative treatment option for myelofibrosis whereas the transplant procedure itself still has high therapy related morbidity and mortality despite recent improvements. A reduced intensity non myeloablative or mini transplant is a conditioning process in which lower doses of chemotherapy and or radiation or none at all are given prior to stem cell transpla. My sister was only a 50 match. For myelofibrosis the procedure uses stem cells from a donor allogeneic stem cell transplant.

British journal of haematology 29 march 2012 sources. If left untreated it could turn into leukemia. This treatment has the potential to cure myelofibrosis but it also carries a high risk of life threatening side effects including a risk that the new stem cells will react against your body s healthy tissues graft versus host disease. Myelofibrosis mf is a clonal myeloproliferative neoplasm mpn that can arise de novo or result from previous polycythemia vera or essential thrombocythemia post et mf.

Bone marrow transplantation is a treatment procedure in which damaged or faulty bone marrow is replaced by healthy bone marrow from a donor. 1 recently reported a significant improvement in outcome of patients with myelofibrosis mf after allogeneic stem cell transplantation sct. Allogeneic stem cell transplantation for myelofibrosis in 2012 donal p. Treating my myelofibrosis with a stem cell transplant.

It is usually risky for older patients and those individuals with other health problems. Mf is characterized by a clonal stem cell process resulting in ineffective erythropoiesis reactive fibrosis in bone marrow and extramedullary hematopoiesis in the spleen or in multiple organs 1. The patient is given chemotherapy or radiation therapy in order to remove defective bone marrow. And because of the variable outcome of patients with myelofibrosis treatment decision with.

Allogeneic stem cell transplantation is the only current treatment with the potential to cure mf but it also carries a high risk of life threatening side effects. A bone marrow aspiration revealed i d developed myelofibrosis a type of bone cancer. It is beneficial to improve the outcomes of this procedure in myelofibrosis. Myelofibrosis is typically treated with a stem cell transplant so i started working with uday popat m d to find a donor.

2 hematopoietic stem cell transplant is the most effective cure for myelofibrosis. Some mf patients present to the transplant center with severe complications after a long disease history and their treatment may be very challenging.